{"id":84,"date":"2019-11-13T04:21:48","date_gmt":"2019-11-13T04:21:48","guid":{"rendered":"https:\/\/www.blythinstitute.org\/site\/?page_id=84"},"modified":"2025-04-20T03:01:25","modified_gmt":"2025-04-20T03:01:25","slug":"facilitated-variation-in-the-genome","status":"publish","type":"page","link":"https:\/\/www.blythinstitute.org\/site\/research\/facilitated-variation-in-the-genome\/","title":{"rendered":"Facilitated Variation in the Genome"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">The discovery of DNA has transformed our view of biology.&nbsp; Biology is not just organized chemicals &#8211; it is information at work.&nbsp; One of the surprising discoveries in recent times is that cells can facilitate their own evolution.&nbsp; Mutations can no longer be assumed to be haphazard accidents &#8211; many of them are triggered by biological processes in the cell to aid them in generating responses to environmental cues or generating &#8220;hedge&#8221; mutations in order to help the population survive catastrophe.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Technical Papers<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Bartlett, Jonathan. &#8220;<a href=\"https:\/\/doi.org\/10.20935\/AcadBiol7432\">Alternate Mutation Modalities in Models of Population Dynamics<\/a>.&#8221; <em>Academia Biology<\/em> 2(4). <a href=\"https:\/\/www.blythinstitute.org\/site\/wp-content\/uploads\/2024\/07\/mutation_modalities_2024_data.zip\">Supplemental Data<\/a>.<\/li>\n\n\n\n<li>Bartlett, Jonathan. 2024. &#8220;<a href=\"https:\/\/doi.org\/10.1017\/S0140525X23002868\">An Updated Perspective on Teleonomy<\/a>.&#8221; <em>Behavioral and Brain Sciences<\/em> 47(e69).<\/li>\n\n\n\n<li>Bartlett, Jonathan.  2023.  &#8220;<a href=\"https:\/\/www.academia.edu\/108570915\/Causal_Capabilities_of_Teleology_and_Teleonomy_in_Life_and_Evolution\">Causal Capabilities of Teleology and Teleonomy in Life and Evolution<\/a>.&#8221;  <em>Organon F<\/em> 30(3):222-254.  DOI 10.31577\/orgf.2023.30301.<\/li>\n\n\n\n<li>Bartlett, Jonathan. 2023. &#8220;<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s10441-023-09464-8\">Random with Respect to Fitness or External Selection?  An Important but Often Overlooked Distinction<\/a>.&#8221; <em>Acta Biotheoretica<\/em> 71(2): DOI 10.1007\/s10441-023-09464-8.  (<a href=\"https:\/\/rdcu.be\/c7W1o\">Published Manuscript<\/a> | <a href=\"https:\/\/www.blythinstitute.org\/site\/wp-content\/uploads\/2024\/05\/RandomRespect.pdf\">Accepted Manuscript PDF<\/a>) <\/li>\n\n\n\n<li>Bartlett, Jonathan.  2020.  &#8220;<a rel=\"noreferrer noopener\" href=\"https:\/\/journals.blythinstitute.org\/ojs\/index.php\/cbi\/article\/view\/71\" target=\"_blank\">Is Active Information Applicable to Biology?<\/a>&#8221;  <em>Communications of the Blyth Institute<\/em> 2(2):44-46.<\/li>\n\n\n\n<li>Holloway, Eric.  2020.  &#8220;<a href=\"https:\/\/journals.blythinstitute.org\/ojs\/index.php\/cbi\/article\/view\/69\" target=\"_blank\" rel=\"noreferrer noopener\">Tutorial: Bioinformatics Basics<\/a>.&#8221;  Communications of the Blyth Institute 2(2):35-38.<\/li>\n\n\n\n<li>Bartlett, Jonathan.  2020.  &#8220;<a href=\"https:\/\/bio-complexity.org\/ojs\/index.php\/main\/article\/view\/BIO-C.2020.2\">Measuring Active Information in Biological Systems<\/a>.&#8221;  <em>BIO-Complexity<\/em> 2020(2):1-11.<\/li>\n\n\n\n<li>Bartlett, Jonathan.  2020.  &#8220;<a rel=\"noreferrer noopener\" aria-label=\"Do Mutation Rates Match the Kelly Criterion? (opens in a new tab)\" href=\"https:\/\/journals.blythinstitute.org\/ojs\/index.php\/cbi\/article\/view\/61\" target=\"_blank\">Do Mutation Rates Match the Kelly Criterion?<\/a>&#8221;  <em>Communications of the Blyth Institute <\/em>2(1):31.<\/li>\n\n\n\n<li>Bartlett, Jonathan.&nbsp; 2019.&nbsp; &#8220;Implications of Two Opposing Variations of Neutral Theory.&#8221;&nbsp;&nbsp;<em>Communications of the Blyth Institute&nbsp;<\/em>1(1):51-52.<\/li>\n\n\n\n<li>Bartlett, Jonathan.\u00a0 2018.\u00a0 &#8220;<a href=\"https:\/\/crsq.creationresearch.org\/id\/eprint\/1213\/1\/Intelligent%20Design%20and%20its%20Place%20in%20the%20Creation%20Model.pdf\">Intelligent Design and Its Place in the Creation Model<\/a>.&#8221;\u00a0\u00a0<em>Creation Research Society Quarterly<\/em>\u00a054:48-56.<\/li>\n\n\n\n<li>Bartlett, Jonathan.&nbsp; 2017.&nbsp; &#8220;<a rel=\"noreferrer noopener\" href=\"http:\/\/www-orig.blythinstitute.org\/images\/data\/attachments\/0000\/0074\/107-732-1-PB.pdf\" target=\"_blank\">Evolutionary Teleonomy as a Unifying Principle for the Extended Evolutionary Synthesis<\/a>.&#8221;&nbsp;&nbsp;<em>BIO-Complexity<\/em>&nbsp;2017(2):1-7.<\/li>\n\n\n\n<li>Bartlett, Jonathan. &nbsp;2017. &nbsp;&#8220;<a rel=\"noreferrer noopener\" href=\"http:\/\/www-orig.blythinstitute.org\/images\/data\/attachments\/0000\/0071\/shortcoming_of_mn.pdf\" target=\"_blank\">Philosophical Shortcomings of Methodological Naturalism and the Path Forward<\/a>.&#8221; &nbsp;In Jonathan Bartlett and Eric Holloway (eds.),&nbsp;<em><a href=\"http:\/\/www.blythinstitute.org\/site\/sections\/66\">Naturalism and Its Alternatives in Scientific Methodologies<\/a><\/em>&nbsp;(pp. 13-38). &nbsp;Broken Arrow, OK: Blyth Institute Press.<\/li>\n\n\n\n<li>Bartlett, Jonathan and Eric Holloway. &nbsp;2017. &nbsp;&#8220;<a rel=\"noreferrer noopener\" href=\"http:\/\/www-orig.blythinstitute.org\/images\/data\/attachments\/0000\/0070\/other_alternatives.pdf\" target=\"_blank\">Other Non-Naturalistic Methodologies in Modern Practice<\/a>.&#8221; &nbsp;In Jonathan Bartlett and Eric Holloway (eds.),&nbsp;<em><a href=\"http:\/\/www.blythinstitute.org\/site\/sections\/66\">Naturalism and Its Alternatives in Scientific Methodologies<\/a><\/em>&nbsp;(pp. 257-268). &nbsp;Broken Arrow, OK: Blyth Institute Press.<\/li>\n\n\n\n<li>Bartlett, Jonathan. &nbsp;2014. &nbsp;&#8220;Surprising Distinguishing Features Characterizing an Apobaramin&#8221; &nbsp;Presented at Origins 2014 Conference. (<a rel=\"noreferrer noopener\" href=\"http:\/\/www-orig.blythinstitute.org\/images\/data\/attachments\/0000\/0046\/Surprising_Distinguishing_Features.rtf\" target=\"_blank\">Abstract<\/a>,&nbsp;<a rel=\"noreferrer noopener\" href=\"http:\/\/www-orig.blythinstitute.org\/images\/data\/attachments\/0000\/0047\/SurprisingDistinguishingFeatures.pdf\" target=\"_blank\">Slides<\/a>)&nbsp;<\/li>\n\n\n\n<li>Bartlett, Jonathan.&nbsp; 2010.&nbsp; &#8220;<a rel=\"noreferrer noopener\" href=\"http:\/\/www-orig.blythinstitute.org\/images\/data\/attachments\/0000\/0017\/estimating_active_information_v5.rtf\" target=\"_blank\">Estimating Active Information in Adaptive Mutagenesis<\/a>&#8221; &nbsp;&nbsp;<em>Occasional Papers of the BSG&nbsp;<\/em>17:2. (<a rel=\"noreferrer noopener\" href=\"http:\/\/www-orig.blythinstitute.org\/images\/data\/attachments\/0000\/0005\/EstimatingActiveInformationPoster_final.pdf\" target=\"_blank\">Poster<\/a>,&nbsp;<a rel=\"noreferrer noopener\" href=\"http:\/\/www-orig.blythinstitute.org\/images\/data\/attachments\/0000\/0004\/estimating_active_information_presentation_slides.pdf\" target=\"_blank\">Slides<\/a>)<\/li>\n\n\n\n<li>Bartlett, Jonathan.&nbsp; 2010.&nbsp; &#8220;<a rel=\"noreferrer noopener\" href=\"http:\/\/www-orig.blythinstitute.org\/images\/data\/attachments\/0000\/0045\/015.pdf\" target=\"_blank\">Irreducible Complexity and Relative Irreducible Complexity: Foundations and Applications<\/a>&#8221;&nbsp;<em>Occasional Papers of the BSG<\/em>&nbsp;15:1-10.<\/li>\n\n\n\n<li>Bartlett, Jonathan. &nbsp;2010. &nbsp;&#8220;<a href=\"http:\/\/www-orig.blythinstitute.org\/images\/data\/attachments\/0000\/0073\/mutation_is_not_random.doc\">Mutation is Not Random<\/a>.&#8221; &nbsp;In E. Norbert Smith (ed.),&nbsp;<em>Sacred Cows in Science<\/em>.<\/li>\n\n\n\n<li>Bartlett, Jonathan.&nbsp; 2009.&nbsp; &#8220;<a rel=\"noreferrer noopener\" href=\"http:\/\/www-orig.blythinstitute.org\/images\/data\/attachments\/0000\/0014\/creationary_classification_mutations.pdf\" target=\"_blank\">Towards a Creationary Classification of Mutations<\/a>&#8221;&nbsp;<em>Answers Research Journal<\/em>&nbsp;2:169-174.<\/li>\n\n\n\n<li>Bartlett, Jonathan.&nbsp; 2008.&nbsp; &#8220;<a rel=\"noreferrer noopener\" href=\"http:\/\/www-orig.blythinstitute.org\/images\/data\/attachments\/0000\/0015\/CRSQ_Fall_08_Bartlett_2_.pdf\" target=\"_blank\">Statistical and Philosophical Notions of Randomness in Creation Biology<\/a>&#8221;&nbsp;<em>Creation Research Society Quarterly<\/em>&nbsp;45(2):91-99.<\/li>\n\n\n\n<li>Bartlett, Jonathan.&nbsp; 2008.&nbsp; &#8220;<a rel=\"noreferrer noopener\" href=\"http:\/\/www-orig.blythinstitute.org\/images\/data\/attachments\/0000\/0011\/complexity_classes.pdf\" target=\"_blank\">Wolfram&#8217;s Complexity Classes, Relative Evolvability, Irreducible Complexity, and Domain-Specific Languages<\/a>&#8221;&nbsp;<em>Occasional Papers of the BSG<\/em>&nbsp;11:5.<\/li>\n\n\n\n<li>Bartlett, Jonathan.&nbsp; 2006.&nbsp; &#8220;<a rel=\"noreferrer noopener\" href=\"http:\/\/www-orig.blythinstitute.org\/images\/data\/attachments\/0000\/0013\/metaprogramming_and_genomics_abstract.pdf\" target=\"_blank\">Metaprogramming and Genomics<\/a>&#8221;&nbsp;<em>Occasional Papers of the BSG<\/em>&nbsp;8:17-18. (<a rel=\"noreferrer noopener\" href=\"http:\/\/www-orig.blythinstitute.org\/images\/data\/attachments\/0000\/0003\/BSG_Poster.pdf\" target=\"_blank\">Poster<\/a>,&nbsp;<a rel=\"noreferrer noopener\" href=\"http:\/\/www-orig.blythinstitute.org\/images\/data\/attachments\/0000\/0010\/BSG_Presentation.pdf\" target=\"_blank\">Slides<\/a>)<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>The discovery of DNA has transformed our view of biology.&nbsp; Biology is not just organized chemicals &#8211; it is information at work.&nbsp; One of the surprising discoveries in recent times is that cells can facilitate their own evolution.&nbsp; Mutations can no longer be assumed to be haphazard accidents &#8211; many of them are triggered by&#8230; <\/p>\n<div class=\"link-more\"><a href=\"https:\/\/www.blythinstitute.org\/site\/research\/facilitated-variation-in-the-genome\/\">Read More<\/a><\/div>\n","protected":false},"author":2,"featured_media":0,"parent":26,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-84","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/www.blythinstitute.org\/site\/wp-json\/wp\/v2\/pages\/84","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.blythinstitute.org\/site\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.blythinstitute.org\/site\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.blythinstitute.org\/site\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.blythinstitute.org\/site\/wp-json\/wp\/v2\/comments?post=84"}],"version-history":[{"count":10,"href":"https:\/\/www.blythinstitute.org\/site\/wp-json\/wp\/v2\/pages\/84\/revisions"}],"predecessor-version":[{"id":1725,"href":"https:\/\/www.blythinstitute.org\/site\/wp-json\/wp\/v2\/pages\/84\/revisions\/1725"}],"up":[{"embeddable":true,"href":"https:\/\/www.blythinstitute.org\/site\/wp-json\/wp\/v2\/pages\/26"}],"wp:attachment":[{"href":"https:\/\/www.blythinstitute.org\/site\/wp-json\/wp\/v2\/media?parent=84"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}